Additional file 6: Figure S3. of DNA methylation profiling identifies novel markers of progression in hepatitis B-related chronic liver disease

Histone deacetylase 4 immunohistochemistry in mild and severe disease: HDAC4 is highly expressed in advanced inflammation and fibrosis. Representative ×200 pictures of HDAC4 immunohistochemistry from five mild (fibrosis stage ≤1) and five severe (fibrosis stage ≥4) chronic liver disease due to hepatitis B infection. DAB-positive staining pattern was detected in myofibroblasts, inflammatory cells and hepatocytes in or near to fibrosis tracts. (TIF 1747 kb)