Additional file 6: Additional Figure S6. of The role of the aryl hydrocarbon receptor in the development of cells with the molecular and functional characteristics of cancer stem-like cells

Ahr and Cyp1b1 expression correlate with expression of stem cell- and migration/invasion-associated genes in the TCGA database. Expression of genes from the cancer genome atlas (TCGA) dataset [68] were ranked based on the correlation of their expression profiles with Ahr (A) and Cyp1b1 (B) expression. The enrichment score (in green) was computed by considering the position of the stem cell- and migration/invasion-associated genes in the ranked list obtained from the TCGA RNA-Seq data. A significant positive correlation between expression of the putative AHR target genes and Ahr or Cyp1b1 expression (P = 0.047, P = 0.0001, respectively) was demonstrated. The ranking of Msi1 demonstrated a low correlation with both Ahr and Cyp1b1 expression. (PDF 100 kb)