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Additional file 5: of Prevention of C5aR1 signaling delays microglial inflammatory polarization, favors clearance pathways and suppresses cognitive loss

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posted on 2017-09-18, 05:00 authored by Michael Hernandez, Shan Jiang, Tracy Cole, Shu-Hui Chu, Maria Fonseca, Melody Fang, Lindsay Hohsfield, Maria Torres, Kim Green, Rick Wetsel, Ali Mortazavi, Andrea Tenner
Dynamic gene expression profiles of 9 clusters. Gene expression clusters were derived from maSigPro. Median profile are plotted across all ages for all the genes in the corresponding cluster. WT (blue), C5aR1KO (red), Arctic (green) and Arctic/C5aR1KO (orange). (DOCX 265 kb)

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National Institute of Neurological Disorders and Stroke

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    Molecular Neurodegeneration

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    C5aC5a receptorAlzheimer’s diseaseComplementMicrogliaMouse modelsBehaviorGene expressionInflammationPhagosome

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    CC BY + CC0

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