Additional file 5: of NMDA receptors mediate synaptic depression, but not spine loss in the dentate gyrus of adult amyloid Beta (Aβ) overexpressing mice

S5. CT100(I716F) overexpression does not influence total dendritic length in adult mice. a Examples of traced DG granule cells of the GluN2Afl/fl mouse line. b The number of intersections analyzed by Sholl analysis is not changed by CT100(I716F) overexpression, GluN2A subunit deletion and GluN2A deletion in combination with CT100(I716F) overexpression. Mean ± SEM. Total dendritic length is not different between the groups. c Examples of traced DG granule cells of the GluN2Bfl/fl mouse line. d Sholl analysis of the number of intersections shows subtle changes in dendritic complexity in GluN2B−/−/CT100(I716F) cells compared to their respective control (GluN2B−/−). Mean ± SEM. Total dendritic length is not different between the groups. Bar graphs show median ± IQR.; dendr. = dendritic, morph. = morphology (PDF 133 kb)