12974_2018_1094_MOESM5_ESM.avi (2.41 MB)

Additional file 5: of Mitochondrial damage and “plugging” of transport selectively in myelinated, small-diameter axons are major early events in peripheral neuroinflammation

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posted on 27.02.2018 by Marija Sajic, Keila Ida, Ryan Canning, Norman Gregson, Michael Duchen, Kenneth Smith
Video S5. High-power time-lapse video of axonal mitochondria labeled with TMRM immediately following laser-induced phototoxic damage to mitochondria. The side of the imaging field left to the white line was not exposed to photo-toxic damage. The imaging field to the right of the white line was exposed to laser-induced photo-toxic damage, using the red laser to specifically damage functional mitochondria. Notably, the number of mobile mitochondria transported into the area exposed to photo-toxic damage appears overwhelmingly biased in the favor of anterograde movement. (AVI 2466 kb)

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National Multiple Sclerosis Society

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