Additional file 5 of Evidence for a novel overlapping coding sequence in POLG initiated at a CUG start codon

Additional file 5 : Figure S5: Potential functional regions of the ORF-Y protein. a. Predicted ORF-Y protein sequences from representatives (Homo sapiens, Mus musculus, Orcinus orca, and Myotis lucifugus) of different mammalian orders were submitted to the TMHMM server for transmembrane domain prediction. Each vertical red bar represents the likelihood of a position being contained within a transmembrane domain; the blue line indicates whether the portion of the protein is predicted to be intracellular; and the purple line indicates whether the portion of the protein is predicted to be extracellular. The color of the horizontal line near the top of each plot indicates, for each position, whether it is most likely to be intracellular, transmembrane, or extracellular. b. Possible motifs predicted by the ELM database for the portion of the ORF-Y protein that is most conserved.