Additional file 5: Figure S5. of Blocking ATP-sensitive potassium channel alleviates morphine tolerance by inhibiting HSP70-TLR4-NLRP3-mediated neuroinflammation

Anti-HSP70 neutralizing antibody did not affect acute morphine analgesic effect. Morphine (10 μg/10 μL, i.t.) with or without anti-HSP70-neutralizing antibody (200 μg/kg, i.t.) were injected into mice and analgesia was assessed at the first day. (n = 6) (data were analyzed by two-way ANOVA). (JPEG 118 kb)