Additional file 5: Figure S4. of Repeated intra-articular injection of allogeneic mesenchymal stem cells causes an adverse response compared to autologous cells in the equine model

Synovial fluid cytology box plots of total nucleated cell count (TNCC), percentage of neutrophils (PMN), and total protein concentration (TP) for synovial joints injected with control media only (95% autologous serum, 5% DMSO and no MSCs). Repeated measures analysis of variance (ANOVA) was used to compare temporal changes in the cytologic outcome variables for each pair of treatment groups (AUTO to FBS and AUTO to ALLO), with horse considered a random effect. These analyses were performed using PROC MIXED, and an autoregressive correlation structure was specified. Treatment group (AUTO, ALLO or FBS), time point, and their interaction were included as factors in the ANOVA. There were no significant differences over time between the groups. (JPG 491 kb)