Additional file 5: Figure S4. of Metformin suppresses cancer initiation and progression in genetic mouse models of pancreatic cancer

The effect of metfomin on AMPK/mTOR signaling. (A) Immunohistochemical staining of p-AMPK and p-mTOR in pancreatic tissues from KPC mice treated with vehicle or metformin. (B) Western blotting assays show the expression of p-AMPK, AMPK, p-mTOR, mTOR, p-P70S6K, and P70S6K in pancreatic tissues from KPC mice treated as indicated. (TIFF 9891 kb)