Additional file 5: Figure S3. of Commensal microbiota modulate gene expression in the skin

WGCNA identifies cutaneous gene modules. (A) Hierarchical clustering of samples prior to network generation (B) thresholding analysis, showing scale-free properties of the network with a chosen soft threshold power of 17. Yellow line indicates an R2 value of 0.8, orange of 0.85, and red of 0.9. (C) WGCNA cluster dendrogram of genes in our dataset, with the module membership highlighted below the dendrogram. Gray indicates genes not belonging to any of the determined modules. Dendrogram represents hierarchical clustering of eigengene modules in relation to each other and colonization condition. (D) Correlation of each module to metadata. For each comparison, the rho value is provided above the p value in parentheses. No modules are significantly correlated with sequencing run. The color of each box in the “Colonization Condition” column indicates the strength of the positive correlation with SPF (blue) or GF (magenta) states. (EPS 6217 kb)