Additional file 4: of Renal allograft rejection, lymphocyte infiltration, and de novo donor-specific antibodies in a novel model of non-adherence to immunosuppressive therapy

CXCR4 and CXCL12 expression. This figure shows quantitative RT-PCR analysis of chemokine and chemokine receptor expression from renal grafts after syngeneic or allogeneic transplantation treated with CyA for 6 or 28 days, or CyA on alternating days until d28. mRNA expression of target genes was normalized to the house-keeping gene HPRT and x-fold expression in comparison to syngeneic Tx d6 is shown. (A) CXCR4 (B) CXCL12. Data is shown as mean ± SEM. Groups consisted of at least 6 animals. Statistical analysis is shown (Mann-Whitney U Test). Significance is shown as *p < 0.05 compared to “SynTxd6”, and # p < 0.05 compared to “Txd28CyAalt”. (PDF 24 kb)