13024_2020_360_MOESM4_ESM.tif (5.7 MB)
Additional file 4 of Parkinson’s disease-related Leucine-rich repeat kinase 2 modulates nuclear morphology and genomic stability in striatal projection neurons during aging
Version 2 2020-03-06, 04:35
Version 1 2020-02-20, 05:23
figure
posted on 2020-03-06, 04:35 authored by Xi Chen, Chengsong Xie, Wotu Tian, Lixin Sun, Wang Zheng, Sarah Hawes, Lisa Chang, Justin Kung, Jinhui Ding, Shengdi Chen, Weidong Le, Huaibin CaiAdditional file 4: Figure S2. No alteration of dendritic complexity in the SPNs of 3-month-old Lrrk2−/− mice. a GFP-labeled SPNs (top panel). 3D reconstruction of the top fluorescent image (bottom panel). Scale bar, 20 μm. b, c Sholl analysis of dendritic complexity GFP-labeled SPNs. N = 5 mice per genotype, 5–9 neurons per animal. Benjamin-Hochberg multiple comparison test, no statistically significant difference was identified. d Dendritic length of GFP-labeled SPNs. N = 5 mice per genotype, 5–9 neurons per animal. Unpaired t-test, p = 0.195. e Soma volume of GFP-labeled SPNs. N = 5 mice per genotype, 5–9 neurons per animal. Unpaired t-test, p = 0.151.
