Additional file 4: of Pan-cancer adaptive immune resistance as defined by the Tumor Inflammation Signature (TIS): results from The Cancer Genome Atlas (TCGA)

Figure S2. In order to assess whether/how cancer cell of origin could directly affect the expression of TIS genes, the observed expression level for each gene versus the expected expression level based on total TIS score was evaluated. Specifically, for each algorithm gene, a linear mixed model (LMM) was fit predicting the gene’s log2 expression from TIS score and cancer type, with cancer type modelled as a random effect. The LMM’s variance term for cancer type was compared to each gene’s marginal variance across TCGA datasets. (PDF 4 kb)