Additional file 4: of Loss of amphiregulin reduces myoepithelial cell coverage of mammary ducts and alters breast tumor growth

Figure S4 Necrosis reduced in solid areas of AREG−/− PyMT tumors. Percentage necrosis in solid and papillary areas of AREG+/+ PyMT (N = 32) and AREG−/− PyMT (N = 22) tumors assessed individually. Significant differences observed between solid areas of AREG+/+ PyMT and AREG−/− PyMT tumors. In addition, papillary regions of both tumor genotypes have little to no necrosis. Statistical analysis performed using Mann–Whitney test. *p < 0.05, ***p < 0.001, ****P < 0.0001. n.s. not significant (PPTX 61 kb)