40478_2019_694_MOESM4_ESM.pdf (2.66 MB)
Additional file 4: of HR23B pathology preferentially co-localizes with p62, pTDP-43 and poly-GA in C9ORF72-linked frontotemporal dementia and amyotrophic lateral sclerosis
journal contribution
posted on 2019-03-13, 05:00 authored by Frederike Riemslagh, Hannes Lans, Harro Seelaar, Lies-Anne Severijnen, Shamiram Melhem, Wim Vermeulen, Eleonora Aronica, R. Pasterkamp, John Swieten, Rob WillemsenFigure S2. ADARB2 staining in C9FTD cases and non-demented controls. A) Staining of ADARB2 in C9ORF72 FTD cases (n = 5) and non-demented control (n = 3) post-mortem brain sections shows some intranuclear inclusions in hippocampus CA and DG. All scale bars are 20 μm B) Immunofluorescence staining of ADARB2 (red) and p62 (green) in hippocampal dentate gyrus reveals ADARB2 punctuated staining and some intranuclear inclusions in both C9ORF72 FTD cases (n = 5) and non-demented controls (n = 3). Scale bars in fluorescent pictures are 10 μm. (PDF 2721 kb)