Additional file 4: of Efficacy and tolerability of anti-programmed death-ligand 1 (PD-L1) antibody (Avelumab) treatment in advanced thymoma

Figure S3. Decrease in regulatory T cells (Tregs) (A-D) and increase in myeloid derived suppressor cells (MDSC) (E-H) following steroids in clinical responders who developed immune-related adverse events (irAEs). Patient 1 (A, E), Patient 3 (B, F), and Patient 6 (C, G) received steroids for irAEs, while patient 8 (D, H) developed clinical response but no irAE for 60 days after documentation of response. Steroids were not used during this time frame. Dashed line denotes timing of steroids and solid line indicates time of clinical response. (JPG 74 kb)