Additional file 4: of A preliminary investigation of circulating extracellular vesicles and biomarker discovery associated with treatment response in head and neck squamous cell carcinoma

Figure S2 Protein-protein interaction network construction by STRING to specific proteins in EVs from NR patients. Predicted interactions for these proteins (n = 67) were obtained from STRING online database ( http://string-db.org ). Top five KEGG pathways related to specific proteins in NR-EVs were pathways in cancer (red; 15 proteins, p = 1.74 × 10− 11), PI3K/AKT signaling pathway (purple; 12 proteins, p = 8.4 × 10− 8), proteoglycans in cancer (green; ten proteins, p = 1.58 × 10− 7), antigen processing and presentation (yellow; six proteins, p = 4.56 × 10− 6) and bladder cancer (lilac; five proteins, p = 5.34 × 10− 6). (DOCX 25 kb)