Additional file 4: Video 2. of Morphological change of CD4+ T cell during contact with DC modulates T-cell activation by accumulation of F-actin in the immunology synapse

The morphology of a CD4+ T cell changes from round to round-flattened during the IS formation. TCR is shown red, ICAM-1 is green, and scale bar is 2 Οm. Before IS formation, TCR was uniformed on the surface of T cell. After IS formation, TCR and ICAM-1 was accumulated at the interface of T-DC.