Additional file 4: Figure S4. of Inflammatory pre-conditioning restricts the seeded induction of α-synuclein pathology in wild type mice

IL-6 expression by itself does not alter p62 levels. Mice were injected at neonatal day P0 with rAAV-IL-6 or rAAV-EV and subsequently injected in the hippocampus with αSyn at 2 months of age. Mice were analyzed 4 months post injection with αSyn fibrils in the hippocampus. Representative sections stained with anti-p62 antibody shows that CNS expression of IL-6 by itself does not produce any overt changes in p62 expression. Scale bar, 80 μm. (1.49 MB)