12943_2017_748_MOESM4_ESM.tif (6.9 MB)
Additional file 4: Figure S3. of HSP90 promotes cell glycolysis, proliferation and inhibits apoptosis by regulating PKM2 abundance via Thr-328 phosphorylation in hepatocellular carcinoma
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posted on 2017-12-20, 05:00 authored by Qiuran Xu, Jianfeng Tu, Changwei Dou, Jun Zhang, Liu Yang, Xin Liu, Kefeng Lei, Zhikui Liu, Yufeng Wang, Lijie Li, Hangxing Bao, Jiahui Wang, Kangsheng TuMG132 restored the protein level of PKM2 induced by HSP90 knockdown. MG-132 was used to inhibit the proteasomal degradation in Hep3B cells. MG-132 treatment led to PKM2 accumulation in the detergent insoluble fraction of the cell lysate. (TIFF 7067Â kb)