Additional file 4: Figure S3. of CD274 promotes cell cycle entry of leukemia-initiating cells through JNK/Cyclin D2 signaling

CD274 has no effect on the differentiation and apoptosis of LICs. (A) Representative flow cytometric plot for the percentages of Mac-1+/Gr-1+ cells in the recipient mice upon secondary transplantation. (B) Quantification results for panel (A) (n = 3, p > 0.05). (C-E) The apoptotic status was examined by the staining with Annexin V and 7-AAD in WT and CD274-null LICs upon the primary (C-D) or secondary transplantation (E-F) (n = 3, p > 0.05). (PDF 190 kb)