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Additional file 4: Figure S3. of Association mapping by pooled sequencing identifies TOLL 11 as a protective factor against Plasmodium falciparum in Anopheles gambiae

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posted on 2015-10-13, 05:00 authored by Seth Redmond, Karin Eiglmeier, Christian Mitri, Kyriacos Markianos, Wamdaogo Guelbeogo, Awa Gneme, Alison Isaacs, Boubacar Coulibaly, Emma Brito-Fravallo, Gareth Maslen, Daniel Mead, Oumou Niare, Sekou Traore, N’Fale Sagnon, Dominic Kwiatkowski, Michelle Riehle, Kenneth Vernick
Manhattan plot for colony Fd03. Results are given for the two replicates individually and the values combined by Fisher’s method. All genotyped loci were tested for association with two phenotypes by logistic regression using PLINK. Infection prevalence (blue) was defined as having more than one oocyst in the dissected midgut, infection intensity (red, measured only for mosquitoes carrying ≥1 oocyst) as having >5 oocysts. Dashed line represents a 0.01 p-value (i.e., 1/p = 100). Genes in the regions are shown below; Toll11 and Toll10 are the two rightmost genes on the positive strand. The combined plot represents values from reps 1 and 2 combined by the method of Fisher [47]. (PDF 127 kb)

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