Additional file 4: Figure S3. of Association mapping by pooled sequencing identifies TOLL 11 as a protective factor against Plasmodium falciparum in Anopheles gambiae

Manhattan plot for colony Fd03. Results are given for the two replicates individually and the values combined by Fisher’s method. All genotyped loci were tested for association with two phenotypes by logistic regression using PLINK. Infection prevalence (blue) was defined as having more than one oocyst in the dissected midgut, infection intensity (red, measured only for mosquitoes carrying ≥1 oocyst) as having >5 oocysts. Dashed line represents a 0.01 p-value (i.e., 1/p = 100). Genes in the regions are shown below; Toll11 and Toll10 are the two rightmost genes on the positive strand. The combined plot represents values from reps 1 and 2 combined by the method of Fisher [47]. (PDF 127 kb)