Additional file 4: Figure S3. of Ablation of epidermal RXRα in cooperation with activated CDK4 and oncogenic NRAS generates spontaneous and acute neonatal UVB induced malignant metastatic melanomas

Changes in the expression of different cellular proteins from the TAN skin in the UVB untreated mice. Quantification of western blot. (a, b) Graphs showing expression of pAKT normalized with AKT and PTEN normalized with actin, no significant change. (c, d, e) Graphs showing expression of p21, cyclin D1 and p53 normalized against actin, with significant increase in p21 (p < 0.05) and cyclin D1 (p < 0.01) and no significant change in p53. (f, g) Graphs showing expression of bax and pro-caspase 3 normalized against actin, with no significant changes in both bax and pro-caspase 3. (TIFF 273 kb)