Additional file 4: Figure S1. of DNA hypomethylation of Synapsin II CpG islands associates with increased gene expression in bipolar disorder and major depression

DNA methylation (percent values) at significant individual CpGs. A-E. Scatter plots represent individual % methylation values for each of the 5 loci found to be significant for at least one diagnostic group (marked with * in Fig. 1) by Least Significant Difference (LSD) post-hoc analyses. F. Average % methylation for the three consequent CpGs shown to be significantly different in MDD compared to CTRL by Least Significant Difference (LSD) post-hoc analyses. The average values were found to be significantly different between the groups (Student’s T-Test, p-value = 0.03). (PPTX 354 kb)