Additional file 3: of Zoledronic acid inhibits the growth of cancer stem cell derived from cervical cancer cell by attenuating their stemness phenotype and inducing apoptosis and cell cycle arrest through the Erk1/2 and Akt pathways

Figure S3. Zoledronic acid induces apoptosis of cervical cancer cells. The histograms show the proportions of DAPI-stained apoptotic SiHa cells derived CSCs, CaSki cells derived CSCs as well as HeLa, SiHa, and CaSki cells after being treated or not with zoledronic acid (10, 20, and 30 μM) (a-b). Western blot analysis of Bcl-2 and Bax in HeLa, SiHa, and CaSki cells treated or not with zoledronic acid (10, 20, and 30 μM) (c). Control vs. 10, 20, and 30 μM zoledronic acid: * P < 0.05, ** P < 0.01. Results are shown as mean values ± SD of independent experiments performed in triplicate. (TIF 819 kb)