Additional file 3 of Salivary proteomic profile of dogs with and without dental calculus

Additional file 3: Supplementary Figure 2. Protein-protein interaction network of the specific proteins identified in dogs with dental calculus, based on STRING database and showing only connected proteins. Most abundant proteins present in the network (Table 4) are marked with a rectangular outline. Legend: ATP-binding cassette, sub-family A, member 13 (ABCA13); Actinin, alpha 4 (ACTN4); AT hook containing transcription factor 1 (AHCTF1); Fructose-bisphosphate aldolase (ALDOA); Annexin (ANXA1); ATR serine/threonine kinase (ATR); B9 protein domain 2; Canis lupus familiaris transforming growth factor, beta 1 (TGFB1), mRNA (B9D2); Canis lupus familiaris calcium-sensing receptor (CASR); Centriolar coiled coil protein 110 kDa (CCP110); Cyclin-dependent kinase 12 (CDK12); Canis lupus familiaris carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1); Uncharacterized protein (CENPF), Centrosomal protein 250 kDa (CEP250); Cytoplasmic linker associated protein 1 (CLASP1); Cytoplasmic linker associated protein 2 (CLASP2); Ceruloplasmin (ferroxidase); Belongs to the multicopper oxidase family (CP); Dedicator of cytokinesis 2; Belongs to the DOCK family (DOCK2); Cyclin N-terminal domain-containing protein (ENSCAFG00000016600); Fas (TNFRSF6) binding factor 1 (FBXO43); Fibronectin (FN1); Uncharacterized protein (GOLGA2); General transcription factor IIF, polypeptide 1, 74 kDa (GTF2F1); HECT domain containing E3 ubiquitin protein ligase 1 (HECTD1); Uncharacterized protein; Belongs to the heat shock protein 70 family (HSPA8); Heat shock protein beta-1 (HSPB1); HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase (HUWE1); Histone-lysine N-methyltransferase; Lysine (K)-specific methyltransferase 2D (KMT2D); Keratin 13 (KRT13); Keratin 3 (KRT3); L-lactate dehydrogenase (LDHA); Glyceraldehyde-3-phosphate dehydrogenase (LOC477441); Histone H3 (LOC483167); Matrix metalloproteinase-9 (MMP9); Nibrin (NBN); non-SMC condensin II complex, subunit D3 (NCAPD3); Condensin complex subunit 2 (NCAPH); Nuclear receptor corepressor 1 (NCOR1); Nuclear receptor corepressor 2 (NOL10); Nucleolar protein 6 (NOL6); Profilin 1 (PFN1); Phosphatidylinositol binding clathrin assembly protein (PICALM); Polycystin 2 (PKD2); Serine/threonine-protein kinase PLK; Polo-like kinase 1 (PLK1); Polymerase (DNA directed), epsilon, catalytic subunit (POLE); Protein phosphatase 1, regulatory subunit 12A (PPP1R12A); Protein tyrosine kinase 2 (PTK2); Uncharacterized protein (RAB3IP); RB1-inducible coiled-coil 1 (RB1CC1); RB binding protein 6, ubiquitin ligase; Retinoblastoma binding protein 6 (RBBP6); Regulatory associated protein of MTOR, complex 1 (RPTOR); U4/U6.U5 tri-snRNP-associated protein 1; Squamous cell carcinoma antigen recognized by T cells (SART1); SEC31 homolog A, COPII coat complex component; SEC31 homolog A (SEC31A); SET domain containing 1A (SETD1A); SH2 domain containing adaptor protein B (SHB); Spectrin, beta, non-erythrocytic 1 (SPTBN1); Uncharacterized protein (SRGAP2); Transaldolase (TALDO1); Transcobalamin I (TCN1); Thrombospondin 1 (THBS1); Tenascin R (TNR); Tumor protein p53 binding protein 1 (TP53BP1); Trafficking protein particle complex 6A (TRAPPC6A); Thyroid hormone receptor interactor 12 (TRIP12); U-box domain containing 5 (UBOX5); Unc-51 like autophagy activating kinase 2 (ULK2); Versican (VCAN). Representation of protein-protein network inside the group of dogs with dental calculus with confidence score adopted at highest confidence-0.900.