Additional file 3: of Post-mortem histopathology underlying β-amyloid PET imaging following flutemetamol F 18 injection

ROC Analysis - Dichotomised BIE (majority read) vs categorical neuropathology. Comparison of the 4 histopathological criteria of assigning abnormal amyloid against a dichotomised (Abnormal/Normal) majority blinded PET Image evaluation. The 4 criteria shown are CERAD [43], National Institutes of Ageing – Reagan Institute AD diagnosis [26], National Institutes of Ageing – Alzheimer’s Association AD diagnosis [25] and Amyloid phase (Phase 3 or greater) [58]. (DOC 201 kb)