Additional file 3: of Phloretin attenuates STAT-3 activity and overcomes sorafenib resistance targeting SHP-1–mediated inhibition of STAT3 and Akt/VEGFR2 pathway in hepatocellular carcinoma

Figure S3. Knockdown of STAT3 and Akt sensitizes PH-induced apoptosis. (A) siRNA against STAT3 enhanced apoptosis in HepG2 and SK-Hep1 cells. (B) siRNA against Akt enhanced apoptosis in HepG2 and SK-Hep1 cells. Experiments were conducted in triplicate and mean values ± SD (bars) are shown. *p<0.05, and **p<0.01 versus control. (DOCX 71 kb)