Additional file 3: of Modifying Rap1-signalling by targeting Pde6δ is neuroprotective in models of Alzheimer’s disease

Figure S2. Reduction in Ca2+ influx through VGCCs reduces ATRA induced toxicity. a The effect of isradipine (VGCC inhibitor) in the toxicity assay (EC50 = 971 nM; n = 2). b The effect of U0126 (ERK1/2 kinase kinase (MEK) inhibitor) in the toxicity assay ((EC50 = 55.88 nM; n = 4) One-way ANOVA, U0126 treatment: P < 0.0001, F = 95.21, DF = 5). (TIF 110 kb)