40478_2019_783_MOESM3_ESM.mp4 (8.57 MB)
Additional file 3: of Ischemic axonal injury up-regulates MARK4 in cortical neurons and primes tau phosphorylation and aggregation
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posted on 2019-08-21, 04:29 authored by Eric Hayden, Jennifer Putman, Stefanie Nunez, Woo Shin, Mandavi Oberoi, Malena Charreton, Suman Dutta, Zizheng Li, Yutaro Komuro, Mary Joy, Gal Bitan, Allan MacKenzie-Graham, Lin Jiang, Jason HinmanMovie S1. Tissue-cleared hemisphere from YFP-H transgenic mouse at 7 days after subcortical ischemic stroke with fluororuby neuronal tracing (red) to identify stroke-injured cortical neurons within sensorimotor cortex overlying a subcortical white matter stroke lesion. Neighboring uninjured (green) and stroke-injured (red) cortical neurons can be identified with a subpopulation of stroke-injured YFP+ neurons (yellow) that were used to measure changes in apical dendrite length after stroke. (MP4 8776 kb)