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Additional file 3 of Humanized tau antibodies promote tau uptake by human microglia without any increase of inflammation
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posted on 2020-05-30, 03:45 authored by Monika Zilkova, Anna Nolle, Branislav Kovacech, Eva Kontsekova, Petronela Weisova, Peter Filipcik, Rostislav Skrabana, Michal Prcina, Tomas Hromadka, Ondrej Cehlar, Gabriela Paulikova Rolkova, Denisa Maderova, Michal Novak, Norbert Zilka, Jeroen J. M. HoozemansAdditional file 3. Supplementary Fig. S. 3 Tau + AX004/IgG1 and Tau + AX004/IgG4 complexes show equivalent stimulation of anti-inflammatory cytokines secretion. The equivalence Tau+AX004/IgG1 and Tau+AX004/IgG4 complexes in stimulating secretion of anti-inflammatory cytokines was evaluated by computing 90% bootstrap confidence intervals of the difference between the means of the corresponding data sets. The confidence intervals were Bonferroni-corrected and compared with equivalence regions defined as +/− 40% of the range of values for each cytokine. In each panel, horizontal lines show the confidence intervals of differences between means (black circles), solid vertical lines show no-difference, and dashed vertical lines show the edges of equivalence regions. The equivalence regions for each cytokine were set as follows (in pg/μg): IL-1β +/− 16.39; IL-6 17.52; TNF-α 8302; IL-4 0.248; IL-10 51.28; IFN-γ 12.61.
