Additional file 3: of Genetic variation in clusterin and risk of dementia and ischemic vascular disease in the general population: cohort studies and meta-analyses of 362,338 individuals

Risk of dementia and ischemic vascular disease as a function of rs9331896 in CGPS. Hazard ratios were multifactorially adjusted for age, sex, body mass index, hypertension, diabetes mellitus, smoking, alcohol consumption, physical inactivity, menopausal status and hormonal replacement therapy (only women), lipid-lowering therapy, and education (left panel). Hazard ratios were further adjusted for APOE genotype (middle panel). Analyses for Alzheimer’s disease, all dementia, and vascular dementia included 93,833 individuals. Analyses for ischemic cerebrovascular disease included 90,923 individuals and those for ischemic heart disease included 86,538 individuals. Analysis of individuals with the APOE ε33 genotype included 52,219 individuals for Alzheimer’s disease, all dementia, and vascular dementia, 50,583 for ischemic cerebrovascular disease, and 48,095 for ischemic heart disease (right panel). (PDF 17 kb)