13046_2019_1372_MOESM3_ESM.jpg (1.26 MB)

Additional file 3: of Cytolytic activity correlates with the mutational burden and deregulated expression of immune checkpoints in colorectal cancer

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posted on 2019-08-21, 04:28 authored by Apostolos Zaravinos, Constantinos Roufas, Majdi Nagara, Beatriz Lucas Moreno, Maria Oblovatskaya, Christodoulos Efstathiades, Christos Dimopoulos, Georgios Ayiomamitis

Figure S3. Gene set variation analysis (GSVA) of known immune-related gene sets (e.g., BIOCARTA_CTL_PATHWAY; TCYTOTOXIC_PATHWAY; TCRA_PATHWAY; THELPER_PATHWAY; PD1_SIGNALING; PRODUCING_DENDRITIC_CELL) showed statistically significant increase in CRCs identified as CYT-high, based on theÂ expression ofÂ GZMA and PRF1. (JPG 1293 kb)

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Cyprus Research Promotion Foundation

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Colorectal cancer Cytolytic activity Classically defined neoepitopes Alternatively defined neoepitopes Mutation burden Immune checkpoints Cancer drivers

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