Additional file 3 of Computing energy landscape maps and structural excursions of proteins

Visualization in 2D of map and paths computed for H-Ras G12D. The computed map for the H-Ras G12D variant is projected onto 2D and projections are color-coded by Rosetta score12 energy values. Low-cost paths (costs in REUs are listed) modeling the On →Off structural excursion are also drawn. The projections of experimentally-known structures on the top two PCs are related by showing whether the structures are captured in the wet laboratory for the WT or variants. (PDF 1823 kb)