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Additional file 3: of Caffeic acid phenethyl ester suppresses androgen receptor signaling and stability via inhibition of phosphorylation on Ser81 and Ser213
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posted on 2019-08-21, 04:26 authored by Ying-Yu Kuo, Chieh Huo, Ching-Yu Lin, Hui-Ping Lin, Jai-Shin Liu, Wen-Ching Wang, Chuang-Rung Chang, Chih-Pin ChuuFigure S3. The nuclear receptor ligand score of three compounds (DHT, CAPE and bicalutamide) was analyzed by sophisticated Bayesian statistics. Molinspiration druglikeness software was used (with sophisticated Bayesian statistics) to compare the ability of DHT, CAPE, and bicalutamide to bind AR. This software compare the structures of representative ligands active on the particular target with structures of inactive molecules and to identify substructure features typical for active molecules ( https://www.molinspiration.com/docu/miscreen/druglikeness.html ). The values revealed the ability to bind with AR. (TIF 5090 kb)