Additional file 3: of A significant risk locus on 19q13 for bipolar disorder identified using a combined genome-wide linkage and copy number variation analysis

Pedigrees included in linkage and CNV weighted analysis for BPD. To retrieve informative pedigrees from the NIMH Genetic Initiative Wave 1–4 sample, 46 pedigrees consisting of 269 genotyped individuals and 97 individuals with no available DNA were selected. Three affection status models were considered (ASM1-3) based on the different bipolar affective disorder sub-types, described in the figure-box. Individuals with a diagnosis of bipolar spectrum disorders which only apply to a certain ASM were coded as “unknown” under the other ASMs. In order to illustrate full details of pedigree composition different subtypes of bipolar spectrum disorders are illustrated. For linkage analyses with different ASMs only genotyped individuals were coded as ASM1-3. All other individuals, irrespective of diagnosis, were coded as ‘unknown’. (PDF 364 kb)