13046_2016_427_MOESM3_ESM.tif (903.8 kB)
Additional file 3: Figure S3. of TIMP1 is a prognostic marker for the progression and metastasis of colon cancer through FAK-PI3K/AKT and MAPK pathway
figure
posted on 2016-09-20, 05:00 authored by Guohe Song, Shifeng Xu, Hong Zhang, Yupeng Wang, Chao Xiao, Tao Jiang, Leilei Wu, Tao Zhang, Xing Sun, Lin Zhong, Chongzhi Zhou, Zhaowen Wang, Zhihai Peng, Jian Chen, Xiaoliang WangSchematic representation for the TIMP1 regulatory pathway proposed in this study. TIMP1 activates FAK/PI3K-AKT and MAPK pathway, which facilitated AKT/ERK phosphorylation. This promotes the activation of BAD, cyclin D1, P21, P27 and other Transcription substrates, leading to potentiation of cell antiapoptosis, proliferation and invasion in CRC. (TIF 903Â kb)
