Additional file 3: Figure S3. of TIMP1 is a prognostic marker for the progression and metastasis of colon cancer through FAK-PI3K/AKT and MAPK pathway

Schematic representation for the TIMP1 regulatory pathway proposed in this study. TIMP1 activates FAK/PI3K-AKT and MAPK pathway, which facilitated AKT/ERK phosphorylation. This promotes the activation of BAD, cyclin D1, P21, P27 and other Transcription substrates, leading to potentiation of cell antiapoptosis, proliferation and invasion in CRC. (TIF 903 kb)