Additional file 3: Figure S3. of Involvement of Ubiquitin-Editing Protein A20 in Modulating Inflammation in Rat Cochlea Associated with Silver Nanoparticle-Induced CD68 Upregulation and TLR4 Activation

2016-05-04T05:00:00Z (GMT) by Hao Feng Ilmari Pyykkö Jing Zou
MCP2+ cells in the rat cochlea 7 days post-intratympanic injection of 0.4 % AgNPs shown by immunofluorescence confocal microscopy or immunohistochemistry. In the cochleae exposed to dH2O, the strial basal cells (SBCs), spiral ligament fibrocytes (SLFs), spiral ganglion cells (SGCs), and hair cells (HCs), pillar cells (PCs), and Deiters’ cells (DCs) of Corti’s organ (CO) showed intensive staining (B, D, and F). 0.4 % AgNPs had no influence on the staining in the SBCs, SLFs, SGCs, and CO (A, C, and E). Comparisons of staining intensity are shown in G and H. Scale bar = 50 μm in A–D and 20 μm in E and F. (JPG 4614 kb)