Additional file 3: Figure S3. of Efficacy of intranasal LaAg vaccine against Leishmania amazonensis infection in partially resistant C57Bl/6 mice

In situ cytokine profile in the chronic phase. Mice (from UFF) were intranasally vaccinated with LaAg and infected with L. amazonensis as described for data in Fig. 3. On day 110 of infection (see Fig. 3), the levels of IFN-γ (a), IL-4 (b), TGF-β (c), IL-10 (d) were measured in the lesion homogenates, and expressed as ng per g of footpad. The data (means ± standard deviations; n = 4–5) are representative of three independent experiments. *P ≤ 0.05 in comparison to PBS controls. (TIF 285 kb)