Additional file 3: Figure S2. of The origin of Rosenthal fibers and their contributions to astrocyte pathology in Alexander disease

Different pattern of GFAP immunostaining in KI homozygous (a, d) in comparison with KI heterozygous (b, e) and TG (c, f) mice. Note that in homozygous KI mice GFAP immunostaining has punctate pattern and delineates oval profiles with bright fluorescence whereas in KI heterozygous and TG mice GFAP immunostaining of astrocytes has a homogeneous pattern. Confocal microcopy. Scale bars: 60 μm in a-c; 20 μm in d-f. (JPG 773 kb)