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Additional file 3: Figure S2. of MCL-1 inhibition provides a new way to suppress breast cancer metastasis and increase sensitivity to dasatinib
figure
posted on 2016-12-08, 05:00 authored by Adelaide I. J. Young, Andrew Law, Lesley Castillo, Sabrina Chong, Hayley Cullen, Martin Koehler, Sebastian Herzog, Tilman Brummer, Erinna Lee, Walter Fairlie, Morghan Lucas, David Herrmann, Amr Allam, Paul Timpson, D. Watkins, Ewan Millar, Sandra O’Toole, David Gallego-Ortega, Christopher Ormandy, Samantha Oakesshowing the apoptotic effect of MCL-1 siRNA and MCL-1 inhibitors on MDA-MB-468-2A and MDA-MB-231-2A, MDA-MB-157 and HCC-1937 cells. (A) MCL-1 siRNA. Bar graphs depicting the average fraction of apoptotic cells, measured as total Annexin V-positive by flow cytometry, for cells and treatments as indicated at 48 hours. Error bars show standard error of the mean. (B) MCL-1 inhibitors. Bar graphs of apoptosis as measured in (A) for cells and treatments as indicated. For A1210477 and UMI-77: + treated with 5 μM, ++ treated with 10 μM. All graphs are the average of three independent experiments. Bars indicate statistically significant groups, p value unpaired t tests. (JPG 1192 kb)
