Additional file 3: Figure S2. of Intravitreal administration of multipotent mesenchymal stromal cells triggers a cytoprotective microenvironment in the retina of diabetic mice

MSC administration does not modify the apoptotic rate in the retina of DM mice. Apoptosis in the retina was analyzed by the TUNEL technique in serial 4-μm eye sections 4 weeks after MSC administration (A) and 12 weeks after MSC administration (B). Nuclei were counterstained with DAPI. Arrows indicate TUNEL-positive cells. The number of apoptotic nuclei was quantified at both experimental times and expressed as fold-change versus normal mice (C and D). Qualitative data are representative of eight eyes per analyzed time. Quantitative data correspond to mean ± SEM of eight eyes per group and per analyzed time. (PNG 3862 kb)