Additional file 3: Figure S2. of Interferon-stimulated genes—essential antiviral effectors implicated in resistance to Theiler’s virus-induced demyelinating disease

ISG15, PKR, and OAS1 protein expression in the spinal cord of mock- and TMEV-infected C57BL/6 at 14 and 98 dpi. ISG15 (A–B), PKR (C–D), and OAS1 (E–F) protein expression in spinal cord gray (A, C, E) and white matter (B, D, F). Shown is the percentage of immunopositive area using Box-and-Whisker plots and significant differences between groups based on Mann-Whitney U tests (*P ≤ 0.05; **P ≤ 0.01). (TIF 3543 kb)