Additional file 3: Figure S2. of Breast primary epithelial cells that escape p16-dependent stasis enter a telomere-driven crisis state

Chromosome instability in 14BPEC. a Abnormal nuclear morphologies. Frequency of abnormal nuclear morphologies per binucleated cell in 14BPECs at initial, medium and late population doubling (PD). b Frequencies of the different types of structural chromosome aberrations observed in metaphase plates of 14BPEC at an early, a mid and a late PD. c Frequencies of aneuploidy in 14BPECs at an early, a mid and a late population doubling. d Frequencies of tetraploidy in 14BPECs at an early, a mid and a late population doubling. BPECs breast primary epithelial cells. (PDF 101 kb)