Additional file 3: Figure S2. of Altered Ca2+ homeostasis induces Calpain-Cathepsin axis activation in sporadic Creutzfeldt-Jakob disease

ER stress in the frontal cortex of sCJD cases. ER stress and Ca2+ induced genes in sCJD MM1 by (A) Western-blot (grp78, hsp27, BDNF, Fas and Bcl-2) and (B) Bcl-2/Bax ratio in the frontal cortex of control and sCJD MM1 cases obtained from the densitometric analysis of both proteins detected by western-blot analysis. Unpaired t-test (95% CI) was used for the comparisons of the two groups. *p < 0.05; **p < 0.01; ***p < 0.001. (PPTX 130 kb)