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Additional file 3: Figure S1. of TLR7-mediated skin inflammation remotely triggers chemokine expression and leukocyte accumulation in the brain

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posted on 2016-05-09, 05:00 authored by Alison McColl, Carolyn Thomson, Louis Nerurkar, Gerard Graham, Jonathan Cavanagh
Transcriptional PBL response of Aldara-treated mice. Mice were treated with 80 mg Aldara cream or control cream every 24 h for 1, 3 or 5 consecutive days. Mice were euthanised 24 h after the final application. Cardiac puncture was performed to retrieve PBLs and RNA was isolated from the tissue. (A) QRT-PCR analysis of the target chemokine genes was performed. n = 4 mice per group. Significance was measured using two-way ANOVA with Bonferroni multiple comparison post-tests ***p ≤ 0.001 **p ≤ 0.01 *p ≤ 0.05. (PNG 32 kb)

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Dr. Mortimer and Theresa Sackler Foundation (GB)

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