Additional file 2: of Pathogenic functions of host microbiota

Area under the receiver-operating characteristic curve (AUC) applying generalized linear mixed-effects models for each disease based on abundances of genes encoding three pathofunctions, namely, the formation of (i) trimethylamine (TMA: cutCD, cntAB and grdH), (ii) the secondary bile acids lithocholic/deoxycholic acid (bai operon) and (iii) hydrogen sulfide (dsr genes) are displayed as well as results from combined data (All). AUCs of individual datasets and of diseases represented by only one dataset based on logistic regression are indicated after arrows on the right and at the bottom, respectively. Data encompassed patients suffering from cardiovascular disease (CVD: I, II), type 2 diabetes (T2D: III-V), obesity (Obese: VI), colorectal cancer (CRC: VII, VIII, IX), liver cirrhosis (Cirr: X) and inflammatory bowel disease (IBD: ulcerative colitis (UC) and Crohn’s disease (CD), XI and XII). Samples from type 1 diabetes (dataset IV), adenomas (datasets VII and VIII) and CD of dataset XI were not considered. For details on individual datasets see Table 2. (PDF 2400 kb)