Additional file 2: of Parallel profiling of DNA methylation and hydroxymethylation highlights neuropathology-associated epigenetic variation in Alzheimerâs disease

Smith, Adam; Smith, Rebecca; Pishva, Ehsan; Hannon, Eilis; Roubroeks, Janou; Burrage, Joe; Troakes, Claire; Al-Sarraj, Safa; Sloan, Carolyn; Mill, Jonathan; van den Hove, Daniel; Lunnon, Katie

doi:10.6084/m9.figshare.7878749.v1

13148_2019_636_MOESM2_ESM.pdf (125.71 kB)

Additional file 2: of Parallel profiling of DNA methylation and hydroxymethylation highlights neuropathology-associated epigenetic variation in Alzheimerâs disease

journal contribution

posted on 2019-03-21, 05:00 authored by Adam Smith, Rebecca Smith, Ehsan Pishva, Eilis Hannon, Janou Roubroeks, Joe Burrage, Claire Troakes, Safa Al-Sarraj, Carolyn Sloan, Jonathan Mill, Daniel van den Hove, Katie Lunnon

Figure S1. Quantile-quantile (Q-Q) plots of expected versus observed P value to check for inflation in linear regression analyses. Q-Q plots are shown for (A) unmodified cytosine (uC) (1-BS data), (B) 5mC (OxBS data), (C) 5hmC (BS â OxBS data), and (D) total DNA modifications (BS data). (PDF 125 kb)

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Alzheimer's Association (US)

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Alzheimerâs disease (AD)Brain Ankyrin 1 (ANK1)DNA methylation (5mC)DNA hydroxymethylation (5hmC)Entorhinal cortex (EC)Epigenetics Epigenome-wide association study (EWAS)Illumina Infinium Human Methylation 450K microarray (450K array)

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