Additional file 2: of Next-generation sequencing identifies monogenic diabetes in 16% of patients with late adolescence/adult-onset diabetes selected on a clinical basis: a cross-sectional analysis

Table S1. Cases with class 3/4/5 variants identified in two genes. Table S2. Loss-of-function variants identified in ABCC8 and KCNJ11. Table S3. List of novel pathogenic (Class 5) or likely pathogenic (Class 4) variants. Table S4. List of known class 4–5 variants identified in ABCC8, HNF1B, KCNJ11, and INS genes. Table S5. Main characteristics of the 15 patients with HNF1B-MODY. Table S6. Main characteristics at the onset of diabetes in patients with monogenic vs. non-monogenic diabetes. Table S7. List of variants of uncertain significance (class 3). Figure S1. Main characteristics at diagnosis of diabetes in patients with monogenic diabetes according to the involved gene. Figure S2. Main characteristics at diagnosis of diabetes in patients with (M+) and without (M−) monogenic diabetes. Figure S3. Hierarchical clustering of 1495 patients with a clinical suspicion of monogenic diabetes. (304 ko). (DOCX 290 kb)