Additional file 2: of Modulation of oxidative phosphorylation and redox homeostasis in mitochondrial NDUFS4 deficiency via mesenchymal stem cells

(A) Representative fluorescence images showing a mouse fibroblast with LMNB BFP-labelled nucleus, a mouse stem cell (mMSC) with Cox8a GFP-labelled mitochondria and a mouse fibroblast containing mitochondria derived from mMSCs. Cell boundaries are stained with phalloidin. (B) Confocal image depicting a mouse fibroblast with Cox8a RFP-labelled mitochondria in co-culture with an mMSC containing Cox8a GFP-labelled mitochondria. (C) Representative confocal images of human cells. Left: human fibroblasts with Cox8a RFP-labelled mitochondria without transferred mitochondria (upper image) or after mitochondrial transfer via hMSCs (lower image). Right: Cox8a GFP-labelled hMSCs with Cox8a GFP-labelled mitochondria without transferred mitochondria (upper image) or after mitochondrial transfer from human fibroblasts (lower image). Scale bar represents 10 Οm. (TIF 912 kb)